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KMID : 0361020090520070566
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Korean Journal of Otolaryngology - Head and Neck Surgery
2009 Volume.52 No. 7 p.566 ~ p.571
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Comparison of the Effect of High-Dose Steroid with That of Super-High-Dose Steroid Therapy in Sudden Sensorineural Hearing Loss
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Park Hyun-Ho
Nam Jeong-Kwon
Choi Jae-Hyuk
Kwon Joong-Keun
Lee Tae-Hoon
Heo Eun-Jeong
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Abstract
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Background and Objectives :Corticosteroids have been used for therapeutic management of sudden sensorineural hearing loss (SSNHL). Because the levels of steroid within inner ear after systemic administration is very low, high-dose steroid regimens have been used. The purpose of this study is to compare the effect of high-dose (HD) steroid therapy with that of super-highdose (SHD) steroid therapy in SSNHL.
Subjects and Method :The study group consisted of 97 patients diagnosed as SSNHL. They were divided into two groups: those who were administered 60 mg prednisolone as the initial high dose (HD group) and those who were administered 1,200 mg hydrocortisone (≒300 mg prednisone) as the super high dose (SHD group).
Results:Hearing improvement was observed in 76.8% of HD group and in 67.9% of SHD group and there was no statistically significant difference in the rate of hearing improvement between HD group and SHD group.
Conclusion:Super-high-dose steroid regimen is not superior to high-dose steroid regimen in the treatment of SSNHL.
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KEYWORD
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Sudden hearing loss, Steroids
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